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Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes

Received: 19 July 2014     Accepted: 17 October 2014     Published: 5 November 2014
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Abstract

Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.

Published in International Journal of Biomedical Science and Engineering (Volume 2, Issue 6-1)

This article belongs to the Special Issue Cancer Research

DOI 10.11648/j.ijbse.s.2014020601.11
Page(s) 1-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Stem Cells, Myelodysplastic Syndrome, Microenvironment, Signaling Pathways, Therapy

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    Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. (2014). Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. International Journal of Biomedical Science and Engineering, 2(6-1), 1-6. https://doi.org/10.11648/j.ijbse.s.2014020601.11

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    Armel Herve Nwabo Kamdje; Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int. J. Biomed. Sci. Eng. 2014, 2(6-1), 1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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    AMA Style

    Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet. Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes. Int J Biomed Sci Eng. 2014;2(6-1):1-6. doi: 10.11648/j.ijbse.s.2014020601.11

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  • @article{10.11648/j.ijbse.s.2014020601.11,
      author = {Armel Herve Nwabo Kamdje and Paul Faustin Seke Etet},
      title = {Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes},
      journal = {International Journal of Biomedical Science and Engineering},
      volume = {2},
      number = {6-1},
      pages = {1-6},
      doi = {10.11648/j.ijbse.s.2014020601.11},
      url = {https://doi.org/10.11648/j.ijbse.s.2014020601.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.s.2014020601.11},
      abstract = {Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.},
     year = {2014}
    }
    

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    AU  - Armel Herve Nwabo Kamdje
    AU  - Paul Faustin Seke Etet
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    N1  - https://doi.org/10.11648/j.ijbse.s.2014020601.11
    DO  - 10.11648/j.ijbse.s.2014020601.11
    T2  - International Journal of Biomedical Science and Engineering
    JF  - International Journal of Biomedical Science and Engineering
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    AB  - Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.
    VL  - 2
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Author Information
  • Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon

  • Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia

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